Abstract
Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Animals
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Anti-Inflammatory Agents / pharmacology
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Cell Line
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Chemistry, Pharmaceutical / methods
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Drug Design
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Humans
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Inflammation
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Mice
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Models, Chemical
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Molecular Structure
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Morpholines / chemical synthesis*
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Morpholines / pharmacology
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Receptor, Cannabinoid, CB2 / agonists*
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Receptor, Cannabinoid, CB2 / chemistry
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Stereoisomerism
Substances
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Analgesics
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Anti-Inflammatory Agents
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Morpholines
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Receptor, Cannabinoid, CB2
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morpholine